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    A recent paper (Li et al.) reports a novel RNA-based Cas-dependent toxin-antitoxin system with the effect of 'addicting' cells to the cassette. Broadly-defined addiction systems could stabilize diverse genomic features, raising the question of the role of selfish elements and intragenomic conflict in the evolution of biological complexity. Copyright © 2021. Published by Elsevier Ltd.


    Scott William Roy. CRISPR-Cas Toxin-Antitoxin Systems: Selfishness as a Constructive Evolutionary Force. Trends in microbiology. 2021 Oct;29(10):869-870

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    PMID: 34376346

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