Rescued from desperation: adult-onset Still's disease with life-threatening interstitial lung disease and macrophage activation : Successful treatment by Tocilizumab.

Guangfeng Zhang, Wenxue Liu, Xiao Zhang, Liang Liu

Zeitschrift fur Rheumatologie 2022 May

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This article presents a case of fulminant interstitial lung disease (ILD) with macrophage activation syndrome (MAS) as a rare complication of adult-onset Still's disease in a 43-year-old male patient. Initial presentation showed severe ILD. Early treatment focused on high-dose corticosteroids; however, disease remission could not be achieved. After an additional inflammatory focus and underlying malignancy were excluded, the triad of pancytopenia, fever, and high ferritin levels indicated MAS; bone marrow biopsy confirmed secondary hemophagocytic histiocytosis. Treatment with tocilizumab induced fast and effective therapeutic success. © 2021. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

Citation

Guangfeng Zhang, Wenxue Liu, Xiao Zhang, Liang Liu. Rescued from desperation: adult-onset Still's disease with life-threatening interstitial lung disease and macrophage activation : Successful treatment by Tocilizumab. Zeitschrift fur Rheumatologie. 2022 May;81(4):335-338