IFNγ signaling integrity in colorectal cancer immunity and immunotherapy.

Wan Du, Timothy L Frankel, Michael Green, Weiping Zou

Cellular & molecular immunology 2022 Jan

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The majority of colorectal cancer patients are not responsive to immune checkpoint blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and ICB-induced antitumor immunity. In this review, we summarize recent advances in the epigenetic, genetic, and functional integrity of the IFNγ signaling pathway in the colorectal cancer microenvironment and its immunological relevance in the therapeutic efficacy of and resistance to ICB. Moreover, we discuss how to target IFNγ signaling to inform novel clinical trials to treat patients with colorectal cancer. © 2021. The Author(s).

Citation

Wan Du, Timothy L Frankel, Michael Green, Weiping Zou. IFNγ signaling integrity in colorectal cancer immunity and immunotherapy. Cellular & molecular immunology. 2022 Jan;19(1):23-32