Association of serum retinol concentration with normal-tension glaucoma.
Ruiqi Pang, Shuo Feng, Kai Cao, Yunxiao Sun, Yiqin Guo, Dandan Ma, Chi Pui Pang, Xiangyi Liu, Jingyu Qian, Yuan Xie, Yan Shi, Hailong He, Jun Peng, Congyan Chen, Jing Cui, Siloka A Labisi, Yue Zhang, Yingdi Fu, Jiaying Li, Yue Wan, Chen Xin, Hanruo Liu, Qing Zhang, Robert N Weinreb, Huaizhou Wang, Ningli Wang
Eye (London, England) 2022 SepTo evaluate the association between serum retinol concentration and normal-tension glaucoma (NTG). A total of 345 study subjects were recruited in a prospective cross-sectional study: 101 patients with NTG, 106 patients with high-pressure primary open-angle glaucoma (POAG) and 138 healthy control subjects. Serum retinol concentration in fasting blood samples was determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). All study subjects were given complete ophthalmic examinations and diagnosed by two glaucoma sub-specialists. Serum retinol concentrations in NTG, POAG, and controls were 338.90 ± 103.23 ng/mL, 405.22 ± 114.12 ng/mL, and 408.84 ± 122.36 ng/mL respectively. NTG patients had lower serum retinol concentrations than POAG (p < 0.001) or healthy controls (p < 0.001). There was no statistical difference between the POAG and healthy controls (p = 0.780). Higher proportion of NTG patients (37.6%) than POAG (17.9%) or controls (21.7%) had serum retinol concentrations lower than 300 ng/mL. Serum retinol was positively correlated with optic nerve sheath diameter (ONSD) (r = 0.349, p = 0.001) in glaucoma patients and not associated with any other demographic features or ophthalmic biometric parameters in the NTG patients. Multivariate logistic regression showed that serum retinol (OR = 0.898, 95CI%: 0.851-0.947) was associated with incident NTG. NTG patients had lower serum retinol concentrations. Serum retinol uniquely associated with NTG makes it a new potential option for the diagnosis and treatment of the disease. © 2021. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.
Citation
Ruiqi Pang, Shuo Feng, Kai Cao, Yunxiao Sun, Yiqin Guo, Dandan Ma, Chi Pui Pang, Xiangyi Liu, Jingyu Qian, Yuan Xie, Yan Shi, Hailong He, Jun Peng, Congyan Chen, Jing Cui, Siloka A Labisi, Yue Zhang, Yingdi Fu, Jiaying Li, Yue Wan, Chen Xin, Hanruo Liu, Qing Zhang, Robert N Weinreb, Huaizhou Wang, Ningli Wang. Association of serum retinol concentration with normal-tension glaucoma. Eye (London, England). 2022 Sep;36(9):1820-1825
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PMID: 34385698
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