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A 79-year-old woman with type 2 diabetes receiving insulin was rushed to our hospital due to severe hypoglycemia. Glucose was administered, and the consciousness disturbance was promptly improved. A few hours later, conjugate deviation of the eyes to the right and left hemiplegia occurred at a normal glucose level. Cerebral magnetic resonance imaging (MRI) showed hyperintensities of the right posterior limb of the internal capsule and the medial thalamus on diffusion-weighted imaging sequences. However, the changes observed using MRI disappeared completely on the third day, and her symptoms subsequently improved. This may have been a case of glucose reperfusion injury.


Erika Sugito, Tetsuro Tsujimoto, Noritoshi Arai, Ryotaro Bouchi, Mitsuru Ohsugi, Akiyo Tanabe, Kohjiro Ueki, Hiroshi Kajio. Left Hemiplegia Possibly Due to Glucose Reperfusion Injury after Recovery of Severe Hypoglycemia in a Woman with Type 2 Diabetes Mellitus. Internal medicine (Tokyo, Japan). 2022 Feb 15;61(4):513-516

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PMID: 34393160

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