Alternate Seizure Spread with Agenesis of the Corpus Callosum.

Agenesis of the corpus callosum is a brain malformation that can occur in isolation or in conjunction with other congenital or developmental defects. The clinical sequelae of this condition include epilepsy, cognitive deficits, developmental delay, and various neurological and psychiatric disorders. Here we present the case of a patient with congenital complete agenesis of the corpus callosum and medically refractory epilepsy who underwent stereoelectroencephalography. This identified a left frontal ictal focus and revealed that contralateral spread occurred though the anterior commissure, a rare and interesting occurrence. Left frontal resection resulted in significant improvement. This demonstrates the role of the anterior commissure in ictal spread and the potential for novel methods of seizure spread in patients with temporal lobe epilepsy that must be considered in a surgical approach. Copyright © 2021 Korean Epilepsy Society.

Citation

Lohit Velagapudi, Caio M Matias, Timothy M Ambrose, Michael R Sperling, Maromi Nei, Chengyuan Wu, Ashwini D Sharan. Alternate Seizure Spread with Agenesis of the Corpus Callosum. Journal of epilepsy research. 2021 Jun;11(1):100-105

PMID: 34395230

search → result