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Primary hepatic neuroendocrine tumors (PHNETs) are rare in dogs, and limited information exists about the treatment of these tumors. A 12-year-old castrated male French bulldog was presented to our clinic with gastrointestinal signs. Diagnostic tests revealed increased hepatic enzyme levels, a mass in the hepatic quadrate lobe, multiple intrahepatic nodules, and enlarged hepatic hilar lymph nodes. The liver mass was diagnosed cytologically as a malignant epithelial tumor suspected to be of neuroendocrine origin. The dog was treated with single-agent toceranib phosphate (TOC) and survived 25.1 months after the initial presentation. On necropsy, a liver mass was found and was subsequently diagnosed as a PHNET on histopathology. To the best of our knowledge, this is the first report of long-term survival in a dog with PHNET treated with TOC.


Masanao Ichimata, Shinichiro Nishiyama, Fukiko Matsuyama, Eri Fukazawa, Kei Harada, Ryuzo Katayama, Atsushi Toshima, Yumiko Kagawa, Tetsushi Yamagami, Tetsuya Kobayashi. Long-term survival in a dog with primary hepatic neuroendocrine tumor treated with toceranib phosphate. The Journal of veterinary medical science. 2021 Oct 05;83(10):1554-1558

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PMID: 34408099

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