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There is very little literature reporting the association of matrix metalloproteinase-1 (MMP1) with personal susceptibility to bladder cancer. In the current study, we carried out the first examination of the contribution of MMP1 rs1799750 to bladder cancer risk in Taiwanese. A total of 375 bladder cancer cases and 375 healthy controls were genotyped for MMP1 rs1799750 via polymerase chain reaction-restriction fragment length polymorphism methodology and this was evaluated for association with clinicopathological factors. The frequencies of MMP1 rs1799750 2G/2G, 1G/2G, and 1G/1G genotypes were 35.7%, 44.8% and 19.5% in the group with bladder cancer and 32.5%, 46.4%, and 21.1% in the healthy control group (p for trend=0.6362). The odds ratios (ORs) for bladder cancer risk after adjusting for age and gender for those carrying 1G/2G and 1G/1G genotypes at MMP1 rs1799750 were 0.88 (95% CI=0.62-1.24, p=0.4357) and 0.83 (95% CI=0.61-1.26, p=0.3990), respectively, compared with the wild-type 2G/2G genotype. In allelic frequency analysis, the adjusted OR for those carrying the 1G allele at MMP1 rs1799750 was 0.87 (95% CI=0.71-1.23, p=0.3479) compared to those people carrying a 2G allele. Our findings indicated that the genotypes at MMP1 rs1799750 appear to play little role in determining personal susceptibility to bladder cancer for Taiwanese. Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.


Cheng-Hsi Liao, Chia-Wen Tsai, Wen-Shin Chang, Zhi-Hong Wang, Chi-Li Gong, Hsi-Chin Wu, Bo-Ren Wang, Shih-Wei Hsu, Wen-Chin Huang, Te-Chun Shen, DA-Tian Bau. Association of Matrix Metalloproteinase-1 Genotypes With Bladder Cancer Risk. In vivo (Athens, Greece). 2021 Sep-Oct;35(5):2535-2540

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PMID: 34410940

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