Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Mechanistic modeling in biology allows to investigate, based on first principles, if putative hypotheses are compatible with observations and to drive further experimental works. Along this line, polymer modeling has been instrumental in 3D genomics to better understand the impact of key mechanisms on the spatial genome organization. Here, I describe how polymer-based models can be practically used to study the role of epigenome in chromosome folding. I illustrate this methodology in the context of Drosophila epigenome folding. © 2022. Springer Science+Business Media, LLC, part of Springer Nature.


Daniel Jost. Polymer Modeling of 3D Epigenome Folding: Application to Drosophila. Methods in molecular biology (Clifton, N.J.). 2022;2301:293-305

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 34415542

View Full Text