Modeling the 3D Genome Using Hi-C and Nuclear Lamin-Genome Contacts.

Jonas Paulsen, Philippe Collas

Methods in molecular biology (Clifton, N.J.) 2022

filter terms:

The three-dimensional (3D) organization of the genome is shaped by interactions with multiple structures within the nucleus, affecting gene expression outcomes. Technological breakthroughs in recent years have generated vast data reflecting various aspects of nuclear genome architecture in space and time. Integrating these datasets into comprehensive 3D genome models can reveal new insights into genome structure and regulation in normal and disease states. In this chapter, we provide a step-by-step guide on how to generate publication-ready integrated 3D genome models from (raw) Hi-C data and from lamin-genome (LAD) contacts. © 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Citation

Jonas Paulsen, Philippe Collas. Modeling the 3D Genome Using Hi-C and Nuclear Lamin-Genome Contacts. Methods in molecular biology (Clifton, N.J.). 2022;2301:337-352