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The Mediator captures CDK7, an attractive transcriptional target in cancer.

Yubao Wang, Cherubin Manokaran, Su Wu, Thomas M Roberts

Cancer cell 2021 Sep 13


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    Cyclin-dependent kinase 7 (CDK7) is implicated in regulating the expression of cancer-dependent genes, and multiple CDK7-targeted therapies are currently under clinical investigation. Three recent studies elucidate the structure of human transcription machinery, offering vital mechanistic insights into CDK7 function and a potential pharmacodynamic marker of CDK7 activity in tumors. Copyright © 2021 Elsevier Inc. All rights reserved.

    Citation

    Yubao Wang, Cherubin Manokaran, Su Wu, Thomas M Roberts. The Mediator captures CDK7, an attractive transcriptional target in cancer. Cancer cell. 2021 Sep 13;39(9):1184-1186

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    PMID: 34416166

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