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Hypotonic-hyporesponsive episode (HHE) after whole cell pertussis vaccination is a known adverse event. Less is known about the risk of HHE after administration of acellular pertussis vaccines. Using parental interviews, this study actively surveyed for HHE among infants after doses 1 and 2 of acellular pertussis vaccine. We interviewed the parents of 52,531 infants. HHE was reported at a rate of 22.8 per 100,000 doses (95% CI: 11.8-39.9) of acellular pertussis vaccine, approximately 45 episodes per 100,000 children. These rates are lower than HHE rates reported after whole cell pertussis vaccines and within the range of HHE rates reported in other studies of acellular pertussis vaccines. Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.


John Hansen, Michael D Decker, Edwin Lewis, Bruce Fireman, Vitali Pool, David P Greenberg, David R Johnson, Steven Black, Nicola P Klein. Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination. The Pediatric infectious disease journal. 2021 Dec 01;40(12):1122-1126

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PMID: 34420008

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