Atherosclerosis: The Culprit and Co-victim of Vascular Dementia.

Vascular dementia (VD), a cerebrovascular disease which causes cognitive impairment, is one of the significant factors that affects the quality of senectitude. Atherosclerosis (AS) is a chronic inflammatory syndrome and closely associated with VD. Analyzing the role of AS in VD contribute greatly to its early detection and prevention, but their relationship has not been integrated into a complete network. This review summarizes AS biomarkers as VD predictors for the first time and describes the direct mechanisms of AS causing VD from five aspects: vascular morphogenesis, hemodynamic change, neurovascular unit damage (NVU), oxidative stress, and microRNA (miRNA). Finally, it discriminates the relationship between AS and VD in common risk factors which can be disease or some molecules. In particular, these data imply that the role of AS in VD is not only a pathogenic factor but also a comorbidity in VD. This review aims to bring new ideas for the prediction and treatment of VD. Copyright © 2021 Huang, Hong and Yang.

Citation

Ya-Ting Huang, Fen-Fang Hong, Shu-Long Yang. Atherosclerosis: The Culprit and Co-victim of Vascular Dementia. Frontiers in neuroscience. 2021;15:673440

PMID: 34421513

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