G-CSF and G-CSF-related vasculitis: a systematic review of the literature and intriguing future research perspectives.

Marta Muzzana, Paolo Pedrazzoli, Angioletta Lasagna

Future oncology (London, England) 2021 Nov

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Background: There are several case reports suggesting that G-CSFs may, in rare conditions, produce serious side effects, such as vasculitis. Materials & methods: A systematic search was conducted in Medline via PubMed, Embase and Cochrane Library to describe this unusual side effect to raise awareness among clinicians for early recognition and treatment. Results: Fifty-seven patients were analyzed. The most prevalent cancer type was breast cancer (47%). Long-acting G-CSF was used in 38 patients (67%). Only 47% of patients were treated with steroids. Conclusion: Although the benefit of G-CSF treatment outweighs the potential damage, oncologists should consider the possibility of triggering a vascular toxicity and try to identify patients at increased risk for this side effect.

Citation

Marta Muzzana, Paolo Pedrazzoli, Angioletta Lasagna. G-CSF and G-CSF-related vasculitis: a systematic review of the literature and intriguing future research perspectives. Future oncology (London, England). 2021 Nov;17(33):4619-4634