Correlation Engine 2.0
Clear Search sequence regions

  • mirnas (4)
  • mirnas (5)
  • pre mirnas (1)
  • research (1)
  • Sizes of these terms reflect their relevance to your search.

    MicroRNA (miRNA) studies have been one of the most popular research areas in recent years. Although thousands of miRNAs have been detected in several species, the majority remains unidentified. Thus, finding novel miRNAs is a vital element for investigating miRNA mediated posttranscriptional gene regulation machineries. Furthermore, experimental methods have challenging inadequacies in their capability to detect rare miRNAs, and are also limited to the state of the organism under examination (e.g., tissue type, developmental stage, stress-disease conditions). These issues have initiated the creation of high-level computational methodologies endeavoring to distinguish potential miRNAs in silico. On the other hand, most of these tools suffer from high numbers of false positives and/or false negatives and as a result they do not provide enough confidence for validating all their predictions experimentally. In this chapter, computational difficulties in detection of pre-miRNAs are discussed and a machine learning based approach that has been designed to address these issues is reviewed. © 2022. Springer Science+Business Media, LLC, part of Springer Nature.


    Müşerref Duygu Saçar Demirci. Computational Detection of Pre-microRNAs. Methods in molecular biology (Clifton, N.J.). 2022;2257:167-174

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 34432278

    View Full Text