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To investigate the relationship between visual impairment (VI) and dementia in the UK Biobank Study. Prospective cohort study. A total of 117,187 volunteers (aged 40-69 years) deemed free of dementia at baseline were included. Habitual distance visual acuity worse than 0.3 logMAR units in the better-seeing eye was used to define VI. The incident dementia was based on electronically linked hospital inpatient and death records. During a median follow-up of 5.96 years, the presence of VI was significantly associated with incident dementia (hazard ratio: 1.78; 95% confidence interval: 1.18-2.68; P = .006). There was a clear trend between the severity of VI and risk of dementia (P for trend = .002). We found VI was associated with increased risk of dementia, with a progressively greater risk among those with worse visual acuity. Our findings suggested that VI might be a modifiable risk factor for dementia and highlighted the potential value of VI elimination to delay the manifestation of dementia. Copyright © 2021 Elsevier Inc. All rights reserved.


Zhuoting Zhu, Danli Shi, Huan Liao, Jason Ha, Xianwen Shang, Yu Huang, Xueli Zhang, Yu Jiang, Longyue Li, Honghua Yu, Wenyi Hu, Wei Wang, Xiaohong Yang, Mingguang He. Visual Impairment and Risk of Dementia: The UK Biobank Study. American journal of ophthalmology. 2022 Mar;235:7-14

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PMID: 34433084

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