The Clinical Impact of the EPH/Ephrin System in Cancer: Unwinding the Thread.

Alexandros Pergaris, Eugene Danas, Dimitrios Goutas, Alexandros G Sykaras, Angelos Soranidis, Stamatios Theocharis

International journal of molecular sciences 2021 Aug 05

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Erythropoietin-producing human hepatocellular receptors (EPHs) compose the largest known subfamily of receptor tyrosine kinases (RTKs). They bind and interact with the EPH family receptor interacting proteins (ephrins). EPHs/ephrins are implicated in a variety of physiological processes, as well as in cancer pathogenesis. With neoplastic disease remaining a leading cause of death world-wide, the development of novel biomarkers aiding in the field of diagnosis, prognosis, and disease monitoring is of utmost importance. A multitude of studies have proven the association between the expression of members of the EPH/ephrin system and various clinicopathological parameters, including disease stage, tumor histologic grade, and patients' overall survival. Besides their utilization in timely disease detection and assessment of outcome, EPHs/ephrins could also represent possible novel therapeutic targets. The aim of the current review of the literature was to present the existing data regarding the association between EPH/ephrin system expression and the clinical characteristics of malignant tumors.

Citation

Alexandros Pergaris, Eugene Danas, Dimitrios Goutas, Alexandros G Sykaras, Angelos Soranidis, Stamatios Theocharis. The Clinical Impact of the EPH/Ephrin System in Cancer: Unwinding the Thread. International journal of molecular sciences. 2021 Aug 05;22(16)