Roles of CCL2-CCR2 Axis in the Tumor Microenvironment.

Suguru Kadomoto, Kouji Izumi, Atsushi Mizokami

International journal of molecular sciences 2021 Aug 08

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Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is one of the major chemokine signaling pathways, and has various functions in tumor progression, such as increasing tumor cell proliferation and invasiveness, and creating a tumor microenvironment through increased angiogenesis and recruitment of immunosuppressive cells. This review discusses the roles of the CCL2-CCR2 axis and the tumor microenvironment in cancer progression and their future roles in cancer therapy.

Citation

Suguru Kadomoto, Kouji Izumi, Atsushi Mizokami. Roles of CCL2-CCR2 Axis in the Tumor Microenvironment. International journal of molecular sciences. 2021 Aug 08;22(16)