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The serum amyloid A1 (SAA1) protein is involved in many pathological diseases. The increased secretion of SAA1 can maintain inflammatory conditions. Acne vulgaris (AV) is a chronic inflammatory disease of pilosebaceous glands and may be associated with systemic manifestations. This study aimed to evaluate the serum level of SAA1 in patients with AV. 120 participants were included in this study: 60 patients with AV and 60 apparently healthy volunteers as a control group. These participants were subjected to dermatological examination and assessments of lipid profile, fasting blood glucose (FBG), and serum SAA1. Both serum SAA1 and FBG are significantly elevated in patients with AV than control (p < 0.0001 and p < 0.001, respectively). Furthermore, there are positive correlations between AV severity and SAA1 and FBG (p < 0.001 and p < 0.0001, respectively). Serum amyloid A1 is increased in AV, and this elevation may play a role in the inflammatory milieu of AV. © 2021 Wiley Periodicals LLC.


Essam Mohamed Akl, Walid A Abdel Halim. Serum level of serum amyloid A1 protein in patients with acne vulgaris. Journal of cosmetic dermatology. 2022 Jun;21(6):2597-2601

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PMID: 34449969

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