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Nitrogen-containing heterocycles (N-heterocycles) are ubiquitous in both organisms and pharmaceutical products. Biocatalysts are providing green approaches for synthesizing various N-heterocycles under mild reaction conditions. This review summarizes the recent advances in the biocatalysis of N-heterocycles through the discovery and engineering of natural N-heterocycle synthetic pathway, and the design of artificial synthetic routes, with an emphasis on biocatalysts applied in retrosynthetic design for preparing complex N-heterocycles. Furthermore, this review discusses the future prospects and challenges of biocatalysts involved in the synthesis of N-heterocycles. Copyright © 2021. Published by Elsevier Inc.


Jing Feng, Wen-Chao Geng, Huifeng Jiang, Bian Wu. Recent advances in biocatalysis of nitrogen-containing heterocycles. Biotechnology advances. 2022 Jan-Feb;54:107813

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PMID: 34450199

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