Molecular Landscape and Computational Screening of the Natural inhibitors against HPV16 E6 Oncoprotein.

Human Papillomavirus (HPV) is a small, non-enveloped, icosahedral and double-stranded DNA virus with a genome of 8 kb, belonging to the papillomaviridae family. HPV has been associated with 99.7% cases of cervical squamous cell carcinoma worldwide. The HPV E6 protein is known as a potent oncogene and is closely allied with the events that result in the malignant transformation of virally infected cells. The present study aims to target plant derived anticancer molecules for HPV driven cancer using a computational approach. In this study, E6 oncoprotein was targeted by 101 plant-derived nutraceuticals using the molecular docking method. The multiple sequence analysis and phylogenetic analysis of low risk and high risk 28 HPV E6 proteins were performed. Withanolide D, Ginkgetin, Theaflavin, Hesperidin, and Quercetin-3-gluconide were identified as the potential inhibitors of HPV 16 E6 protein. The zinc finger domain was identified on all variants of HPV E6 oncoprotein while high-risk HPV18, HPV31, HPV33, HPV35, HPV39, HPV45, HPV58, HPV68 and HPV73: probable risk HPV53 and low-risk HPV43 and HPV70 contain PDZ domain. The current study using bioinformatics analysis approaches reveals a promising platform for developing anti-cancerous competitive inhibitors targeting HPV.
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Citation

Tanzil Juneja, Medha D Pandya, Sejal Shah. Molecular Landscape and Computational Screening of the Natural inhibitors against HPV16 E6 Oncoprotein. Asian Pacific journal of cancer prevention : APJCP. 2021 Aug 01;22(8):2461-2469

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PMID: 34452559

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