Ketone bodies for the failing heart: fuels that can fix the engine?

Salva R Yurista, Christopher T Nguyen, Anthony Rosenzweig, Rudolf A de Boer, B Daan Westenbrink

Trends in endocrinology and metabolism: TEM 2021 Oct

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Accumulating evidence suggests that the failing heart reverts energy metabolism toward increased utilization of ketone bodies. Despite many discrepancies in the literature, evidence from both bench and clinical research demonstrates beneficial effects of ketone bodies in heart failure. Ketone bodies are readily oxidized by cardiomyocytes and can provide ancillary fuel for the energy-starved failing heart. In addition, ketone bodies may help to restore cardiac function by mitigating inflammation, oxidative stress, and cardiac remodeling. In this review, we hypothesize that a therapeutic approach intended to restore cardiac metabolism through ketone bodies could both refuel and 'repair' the failing heart. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Salva R Yurista, Christopher T Nguyen, Anthony Rosenzweig, Rudolf A de Boer, B Daan Westenbrink. Ketone bodies for the failing heart: fuels that can fix the engine? Trends in endocrinology and metabolism: TEM. 2021 Oct;32(10):814-826