Type I, II, and III Interferon Signatures Correspond to Coronavirus Disease 2019 Severity.

We analyzed plasma levels of interferons (IFNs) and cytokines, and expression of IFN-stimulated genes in peripheral blood mononuclear cells in patients with coronavirus disease 2019 of varying disease severity. Patients hospitalized with mild disease exhibited transient type I IFN responses, while intensive care unit patients had prolonged type I IFN responses. Type II IFN responses were compromised in intensive care unit patients. Type III IFN responses were induced in the early phase of infection, even in convalescent patients. These results highlight the importance of early type I and III IFN responses in controlling coronavirus disease 2019 progression. © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

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Myung-Ho Kim, Shadi Salloum, Jeffrey Y Wang, Lai Ping Wong, James Regan, Kristina Lefteri, Zachary Manickas-Hill, Ce Gao, Jonathan Z Li, Ruslan I Sadreyev, Xu G Yu, Raymond T Chung, MGH COVID-19 Collection & Processing Team. Type I, II, and III Interferon Signatures Correspond to Coronavirus Disease 2019 Severity. The Journal of infectious diseases. 2021 Sep 01;224(5):777-782

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PMID: 34467988

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