Hypertrophic pachymeningitis in eosinophilic granulomatosis with polyangiitis.

Shinji Izuka, Hiroyuki Yamashita, Yuko Takahashi, Hiroshi Kaneko

Modern rheumatology case reports 2022 Jan 07

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Eosinophilic granulomatosis with polyangiitis (EGPA) is one of the anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), which is characterised by systemic small vessels vasculitis with associated eosinophilia. Hypertrophic pachymeningitis (HP) is an inflammatory disease in which the cerebral or spinal dura mater is thickened. AAV other than EGPA may sometimes develop HP; however, patients with EGPA rarely develop HP. This is the case of myeloperoxidase-ANCA-positive EGPA that presented with headache and blurred vision and was diagnosed with HP. It was successfully treated with pulsed steroid therapy and intravenous cyclophosphamide without any relapse for more than 4 years. © Japan College of Rheumatology 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Citation

Shinji Izuka, Hiroyuki Yamashita, Yuko Takahashi, Hiroshi Kaneko. Hypertrophic pachymeningitis in eosinophilic granulomatosis with polyangiitis. Modern rheumatology case reports. 2022 Jan 07;6(1):80-82