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    Riboflavin is an essential nutrient for humans and animals, and its derivatives flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are cofactors in the cells. Therefore, riboflavin and its derivatives are widely used in the food, pharmaceutical, nutraceutical and cosmetic industries. Advances in biotechnology have led to a complete shift in the commercial production of riboflavin from chemical synthesis to microbial fermentation. In this review, we provide a comprehensive review of biotechnologies that enhance riboflavin production in microorganisms, as well as representative examples. Firstly, the synthesis pathways and metabolic regulatory processes of riboflavin in microorganisms; and the current strategies and methods of metabolic engineering for riboflavin production are systematically summarized and compared. Secondly, the using of systematic metabolic engineering strategies to enhance riboflavin production is discussed, including laboratory evolution, histological analysis and high-throughput screening. Finally, the challenges for efficient microbial production of riboflavin and the strategies to overcome these challenges are prospected. Copyright © 2021 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.


    Jiajia You, Xuewei Pan, Chen Yang, Yuxuan Du, Tolbert Osire, Taowei Yang, Xian Zhang, Meijuan Xu, Guoqiang Xu, Zhiming Rao. Microbial production of riboflavin: Biotechnological advances and perspectives. Metabolic engineering. 2021 Nov;68:46-58

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    PMID: 34481976

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