HCV egress - unconventional secretion of assembled viral particles.

It is believed that hepatitis C virus (HCV) particles are released through the canonical secretory route: from the endoplasmic reticulum (ER), via the Golgi, to the plasma membrane. While the Golgi is important for HCV release per se, its direct involvement in the trafficking of assembled virions has not yet been established. In fact, data from studies analyzing HCV egress are compatible with several potential pathways of HCV secretion. Here, we summarize and discuss the current knowledge related to the HCV export pathway. Apart from the prototypical anterograde transport, possible routes of HCV release include ER-to-endosomal transport, secretory autophagy, and poorly described mechanisms of unconventional protein secretion. Studying HCV egress promises to shed light on unconventional cellular trafficking and secretory routes. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Maximilian Bunz, Michael Ritter, Michael Schindler. HCV egress - unconventional secretion of assembled viral particles. Trends in microbiology. 2022 Apr;30(4):364-378

Mesh Tags

PMID: 34483048

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