Correlation Engine 2.0
Clear Search sequence regions

  • amino acids (1)
  • brain (1)
  • brain neoplasms (1)
  • carbon (1)
  • diagnosis (1)
  • glioma (8)
  • humans (1)
  • nitrogen (1)
  • patient (1)
  • prognosis (1)
  • Sizes of these terms reflect their relevance to your search.

    The frequent occurrence of neomorphic isocitrate dehydrogenase 1 (IDH1) mutations in low-grade glioma led to an IDH-centric classification of these tumors. However, exploiting metabolic alterations of glioma for diagnostic imaging and treatment has marginally improved patients' prognosis. Here we discuss the nutritional microenvironment of glioma, shaped by the distinctive dependence of the brain on glucose and ketone bodies for energy, and on amino acids for neurotransmission. We highlight the progress in metabolic applications for glioma diagnosis and therapy, and present a map that streamlines the rewired glioma metabolism. The map illustrates the altered reactions in central carbon and nitrogen metabolism that drive glioma biology, and represent metabolic vulnerabilities with translational potential. Copyright © 2021 Elsevier Ltd. All rights reserved.


    Ruhi Deshmukh, Maria Francesca Allega, Saverio Tardito. A map of the altered glioma metabolism. Trends in molecular medicine. 2021 Nov;27(11):1045-1059

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 34489164

    View Full Text