Correlation Engine 2.0
Clear Search sequence regions

  • blood flow (1)
  • brain (6)
  • donor (2)
  • eeg (2)
  • electroencephalogram (1)
  • humans (1)
  • injuries (1)
  • ischaemia (8)
  • nitric oxide (5)
  • nitrite (1)
  • patients (6)
  • phase (1)
  • sodium nitrite (6)
  • suggest (1)
  • Sizes of these terms reflect their relevance to your search.

    Subarachnoid haemorrhage (SAH) is associated with long-term disability, serious reduction in quality of life and significant mortality. Early brain injury (EBI) refers to the pathological changes in cerebral metabolism and blood flow that happen in the first few days after ictus and may lead on to delayed cerebral ischaemia (DCI). A disruption of the nitric oxide (NO) pathway is hypothesised as a key mechanism underlying EBI. A decrease in the alpha-delta power ratio (ADR) of the electroencephalogram has been related to cerebral ischaemia. In an experimental medicine study, we tested the hypothesis that intravenous sodium nitrite, an NO donor, would lead to increases in ADR. We studied 33 patients with acute aneurysmal SAH in the EBI phase. Participants were randomised to either sodium nitrite or saline infusion for 1 h. EEG measurements were taken before the start of and during the infusion. Twenty-eight patients did not develop DCI and five patients developed DCI. In the patients who did not develop DCI, we found an increase in ADR during sodium nitrite versus saline infusion. In the five patients who developed DCI, we did not observe a consistent pattern of ADR changes. We suggest that ADR power changes in response to nitrite infusion reflect a NO-mediated reduction in cerebral ischaemia and increase in perfusion, adding further evidence to the role of the NO pathway in EBI after SAH. Our findings provide the basis for future clinical trials employing NO donors after SAH. © 2021. The Author(s).


    Alexander Luettich, Edit Franko, Desiree B Spronk, Catherine Lamb, Rufus Corkill, Jash Patel, Martyn Ezra, Kyle T S Pattinson. Beneficial Effect of Sodium Nitrite on EEG Ischaemic Markers in Patients with Subarachnoid Haemorrhage. Translational stroke research. 2022 Apr;13(2):265-275

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 34491543

    View Full Text