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    The chroman-4-one framework is a significant structural entity that belongs to the class of oxygen-containing heterocycles. It acts as a major building block in a large class of medicinal compounds, and synthetic compounds exhibit a broad variety of remarkable biological and pharmaceutical activities. Several studies have been performed to improve the methodologies of 4-chromanone-derived compounds. This review focuses on the major synthetic methods of preparation reported on chroman-4-one derivatives from 2016 to 2021.


    Elizabeth J Diana, U S Kanchana, Thomas V Mathew. Current developments in the synthesis of 4-chromanone-derived compounds. Organic & biomolecular chemistry. 2021 Sep 29;19(37):7995-8008

    PMID: 34494068

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