Glycosaminoglycans in Neurodegenerative Diseases.

Weihua Jin, Fuming Zhang, Robert J Linhardt

Advances in experimental medicine and biology 2021

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Glycosaminoglycans (GAGs) are linear polysaccharides that consist of alternating disaccharides sequences of uronic acids and/or galactose hexamino sugars most of which are sulfated. GAGs are ubiquitously expressed on the cell surface, in the intracellular milieu and in the extracellular matrix of all animal cells. Thus, GAGs exhibit many essential roles in a variety of physiological and pathological processes. The targets of GAGs are GAG-binding proteins and related proteins that are of significant interest to both the academic community and in the pharmaceutical industry. In this review, the structures of GAGs, their binding proteins, and analogs are presented that further the development of GAGs and their analogs for the treatment of neurodegenerative diseases agents. © 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.

Citation

Weihua Jin, Fuming Zhang, Robert J Linhardt. Glycosaminoglycans in Neurodegenerative Diseases. Advances in experimental medicine and biology. 2021;1325:189-204