Diabetes and pancreatic cancer: Exploring the two-way traffic.

Pancreatic cancer (PC) is often associated with a poor prognosis. Long-standing diabetes mellitus is considered as an important risk factor for its development. This risk can be modified by the use of certain antidiabetic medications. On the other hand, new-onset diabetes can signal towards an underlying PC in the elderly population. Recently, several attempts have been made to develop an effective clinical tool for PC screening using a combination of history of new-onset diabetes and several other clinical and biochemical markers. On the contrary, diabetes affects the survival after treatment for PC. We describe this intimate and complex two-way relationship of diabetes and PC in this review by exploring the underlying pathogenesis. ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

Citation

Ayan Roy, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Dukhabandhu Naik, Pazhanivel Mohan, Raja Kalayarasan. Diabetes and pancreatic cancer: Exploring the two-way traffic. World journal of gastroenterology. 2021 Aug 14;27(30):4939-4962

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PMID: 34497428

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