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    The exploitation of nitrogen-functionalized reactive intermediates plays an important role in the synthesis of biologically relevant scaffolds in the field of pharmaceutical sciences. Those based on gold carbenes carry a strong potential for the design of highly efficient cascade processes toward the synthesis of compounds containing a fused indole core structure. This personal account gives a detailed explanation of our contribution to this sector, and embraces the reaction development of efficient gold-catalyzed cascade processes based on diversely functionalized azido-alkynes. Challenging cyclizations and their subsequent application in the synthesis of pharmaceutically relevant scaffolds and natural products conducted in an intra- or intermolecular fashion are key features of our research. © 2021 The Chemical Society of Japan & Wiley-VCH GmbH.


    Luca C Greiner, Junpei Matsuoka, Shinsuke Inuki, Hiroaki Ohno. Azido-Alkynes in Gold(I)-Catalyzed Indole Syntheses. Chemical record (New York, N.Y.). 2021 Dec;21(12):3897-3910

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    PMID: 34498385

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