Trimeric chalchonoids from the total phenolic extract of Chinese dragon's blood (the red resin of Dracaena cochinchinensis).

Four new chalchonoid trimers, named cochinchinenins N-Q (1-4), along with a pair of known enantiomers (5-6), were isolated from the total phenolic extract of Chinese dragon's blood (the red resin of Dracaena cochinchinensis). The planar structures of 1-4 were elucidated by extensive spectroscopic analysis including HRESIMS and 1D/2D NMR. The absolute configurations of new compounds were established by ECD data. Compound 1 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 value of 11.5 ± 1.7 μM. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Dao-Ran Pang, Qiu-Yu Zou, Zhi-Xiang Zhu, Xin-Yu Wang, Yu-Jie Pei, Hui-Xia Huo, Yun-Fang Zhao, Peng-Fei Tu, Jiao Zheng, Jun Li. Trimeric chalchonoids from the total phenolic extract of Chinese dragon's blood (the red resin of Dracaena cochinchinensis). Fitoterapia. 2021 Oct;154:105029

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PMID: 34506872

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