Phenytoin: Shepherd or Wolf in Disguise? Phenytoin-Induced Neurotoxicity: A Case Series.

Manali Arora, Deb K Boruah, Vishal Thakker, Sangeeta Bhanwra

Neurology India 2021 Jul-Aug

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Phenytoin is a commonly used antiepileptic drug for various types of seizure disorders except for absent seizures. Long-term dose-dependent neurological side effects of phenytoin therapy include cerebellar atrophy, cerebral atrophy, and brain stem atrophy. Skull hyperostosis, gum hypertrophy, and megaloblastic anemia are other known effects of long-term therapy. We present four cases depicting clinical and neuroimaging findings of phenytoin-induced toxicity.

Citation

Manali Arora, Deb K Boruah, Vishal Thakker, Sangeeta Bhanwra. Phenytoin: Shepherd or Wolf in Disguise? Phenytoin-Induced Neurotoxicity: A Case Series. Neurology India. 2021 Jul-Aug;69(4):1014-1017