Unusual lung tumors-from morphology to genetics.

Jennifer M Boland

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2022 Jan

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Most pathologists are well versed in the diagnosis of lung cancer, given the common nature of the disease. Occasionally more unusual neoplasms are encountered in lung biopsies and resections, which may be difficult to distinguish from "run of the mill" lung cancer cases based on overlapping morphologic and immunophenotypic features. The accurate diagnosis of these rare entities is quite challenging and requires careful morphological examination paired with judicious use of ancillary immunohistochemical and genetic studies. Herein, the clinicopathological and genetic features of five unusual lung tumors will be reviewed, including thoracic SMARCA4-deficient undifferentiated tumor, NUT carcinoma, sclerosing pneumocytoma, primary pulmonary myxoid sarcoma/angiomatoid fibrous histiocytoma, and bronchiolar adenoma/ ciliated muconodular papillary tumor. Since recognition of these entities by pathologists is of increasing importance to guide prognosis and therapy, emphasis will be placed on practical tips to reach these rare diagnoses with confidence. © 2021. The Author(s), under exclusive licence to United States & Canadian Academy of Pathology.

Citation

Jennifer M Boland. Unusual lung tumors-from morphology to genetics. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2022 Jan;35(Suppl 1):57-65