Polyphenols affect the humoral response in cancer, infectious and allergic diseases and autoimmunity by modulating the activity of TH1 and TH2 cells.

Monica Benvenuto, Chiara Focaccetti, Sara Ciuffa, Sara Fazi, Arianna Bei, Martino Tony Miele, Loredana Albonici, Loredana Cifaldi, Laura Masuelli, Roberto Bei

Current opinion in pharmacology 2021 Oct

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Polyphenols are a wide class of natural substances, pleiotropic molecules capable of modulating several processes, involved in the humoral and cellular immune response. The activation, differentiation of B cells, and production of antibodies to protein antigens by plas ma cells depend on T helper (TH) CD4+ cells and secreted cytokines. Cancer, infectious, allergic, and autoimmune diseases are characterized by an imbalance of TH1/TH2 immunity and abnormal activation of the humoral response. Accordingly, polyphenols modulate the TH1/TH2 ratio, the secretion of multiple cytokines, the levels of antibodies, and therefore could contribute to recovering the state of health in these diseases. In this review, we summarize the current knowledge on the effects of polyphenols in modulating the humoral response in cancer, infectious and allergic diseases and in autoimmunity by affecting the activity of TH1 and TH2 cells. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Monica Benvenuto, Chiara Focaccetti, Sara Ciuffa, Sara Fazi, Arianna Bei, Martino Tony Miele, Loredana Albonici, Loredana Cifaldi, Laura Masuelli, Roberto Bei. Polyphenols affect the humoral response in cancer, infectious and allergic diseases and autoimmunity by modulating the activity of TH1 and TH2 cells. Current opinion in pharmacology. 2021 Oct;60:315-330