Methyl-linked Pyrazoles: Synthetic and Medicinal Perspective.

Pyrazoles, an important and well-known class of the azole family, have been found to show a large number of applications in various fields, especially medicinal chemistry. Pyrazole derivatives, particularly methyl-substituted pyrazoles, have been reported as potent medicinal scaffolds that exhibit a wide spectrum of biological activities. The present review is an attempt to highlight the detailed synthetic approaches for methyl-substituted pyrazoles along with an in-depth analysis of their respective medical significances till March 2021. It is hoped that literature sum-up in the form of present review article would certainly be a great tool in assisting medicinal chemists in generating new leads possessing pyrazole nucleus with high efficacy and less microbial resistance. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Citation

Tulika Sharma, Joginder Singh, Bijender Singh, Ramesh Kataria, Vinod Kumar. Methyl-linked Pyrazoles: Synthetic and Medicinal Perspective. Mini reviews in medicinal chemistry. 2022;22(5):770-804

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PMID: 34521325

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