Circulating exosomal miRNAs and cancer early diagnosis.

L Zhu, L Zhao, Q Wang, S Zhong, X Guo, Y Zhu, J Bao, K Xu, S Liu

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2022 Mar

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Microribonucleic acids (miRNAs) are small non-coding ribonucleic acids (ncRNAs), which can affect recognition of homologous sequences and interfere with transcription. It plays key roles in the initiation, development, resistance, metastasis or recurrence of cancers. Identifying circulatory indicators will positively improve the prognosis and quality of life of patients with early cancer. Previous studies have shown that miRNA is highly involved in cancer. In addition, miRNA derived from cancers can be encapsulated as exosomes and further extracted into circulatory systems to realize malignant functions. It indicates that circulating exosome-derived miRNAs have the potential to replace conventional biomarkers as cancer derived exosomes carrying miRNAs can be identified by specific markers and might be more stable and accurate for early diagnosis. © 2021. Federación de Sociedades Españolas de Oncología (FESEO).

Citation

L Zhu, L Zhao, Q Wang, S Zhong, X Guo, Y Zhu, J Bao, K Xu, S Liu. Circulating exosomal miRNAs and cancer early diagnosis. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2022 Mar;24(3):393-406