Overexpression of RNF126 is associated with poor prognosis and contributes to the progression of lung adenocarcinoma.

Zhaona Sun, Xin Liu, Meiyuan Chen, Hong Zhang, Xiancong Zeng

Biomarkers in medicine 2021 Oct

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Aim: To document the expression and function of RNF126 in lung adenocarcinoma (LAD). Materials & methods: A total of 102 LAD patients were enrolled in this retrospective study. The mRNA and protein levels of RNF126 were tested via RT-qPCR and immunohistochemical staining, respectively. Univariate and multivariate analyses were conducted to exploring the clinical significance of RNF126 in the prognosis. Knockdown and overexpression strategies were used to validate the tumor-related roles of RNF126 both in vitro and in vivo. Results: RNF126 was highly expressed and was an independent predictor of a poor prognosis for LAD patients. We also revealed that RNF126 knockdown suppressed proliferation of LAD cells and xenografts. Conclusion: RNF126 is a potential survival predictor and therapeutic target for LAD.

Citation

Zhaona Sun, Xin Liu, Meiyuan Chen, Hong Zhang, Xiancong Zeng. Overexpression of RNF126 is associated with poor prognosis and contributes to the progression of lung adenocarcinoma. Biomarkers in medicine. 2021 Oct;15(15):1345-1355