HIST1H2BN induced cell proliferation and EMT phenotype in prostate cancer via NF-κB signal pathway.

Juan Zhang, Yuhan Chang, Haiyan Xia, Luwei Xu, Xiaowei Wei

Genes & genomics 2021 Nov

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The potential role of HIST1H2BN in prostate cancer remains unclear. To evaluate the carcinogenic role of HIST1H2BN in prostate cancer. The expression of HIST1H2BN in prostate cancer was analyzed using TCGA database and clinical samples. The roles and mechanisms of HIST1H2BN were investigated in DU145 and PC3 cells. HIST1H2BN was significantly upregulated in prostate cancer. HIST1H2BN knockdown inhibited cell proliferation, migration and EMT phenotype in prostate cancer cells. Downregulating HIST1H2BN diminished the expression and binding activity of NF-κB p65, then influenced the expression of MMP2 and MMP9. CONCLUSION : This is the first study to elaborate a HIST1H2BN-NF-κB-EMT regulatory axis in oncogenesis, indicating that HIST1H2BN might be potential therapeutic target for prostate cancer. © 2021. The Genetics Society of Korea.

Citation

Juan Zhang, Yuhan Chang, Haiyan Xia, Luwei Xu, Xiaowei Wei. HIST1H2BN induced cell proliferation and EMT phenotype in prostate cancer via NF-κB signal pathway. Genes & genomics. 2021 Nov;43(11):1361-1369