The acute paraquat poisoning mortality (APPM) score to predict the risk of death in paraquat-poisoned patients.

Chun-Kuei Chen, Yen-Chia Chen, Bruno Mégarbane, Ying-Tse Yeh, Chung-Hsien Chaou, Chia-Hsun Chang, Chih-Chuan Lin

Clinical toxicology (Philadelphia, Pa.) 2022 Apr

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Mortality prediction in paraquat poisoning is a major issue since most prediction rules are inapplicable if the exact ingestion time cannot be determined and/or the serum paraquat concentration is not readily available, as in most countries. Therefore, we aimed to develop and validate a new prediction rule not requiring these two parameters. We designed a 10-year observational cohort study including all consecutive paraquat-poisoned patients managed in two Taiwanese hospitals. We built one cohort to define and one cohort to validate this prediction rule. Parameters independently related to mortality determined using a multivariate analysis were used to formulate the Acute Paraquat Poisoning Mortality (APPM) score. Overall, 321 paraquat-poisoned patients were included, 156 in the derivation and 165 in the validation cohort. Mortality rates in the derivation and validation cohorts were 73% and 81%, respectively (p = 0.20). The three parameters chosen of 28-day mortality at presentation were urine paraquat level >10 ppm (using a colorimetric sodium dithionite-based test; odds ratio (OR), 12.70; 95% confidence interval (CI), 2.64-61.24), white blood cells >13.0 G/L (OR, 5.50; CI, 1.41-21.48) and blood glucose >140 mg/dL [7.8 mmol/L] (OR, 7.45; CI, 1.70-32.86). In the derivation cohort, the area under the ROC curve (AUC-ROC) of the APPM score did not significantly differ from AUC-ROCs of serum paraquat (0.95, p = 0.25) and the Severity Index of Paraquat Poisoning (0.95, p = 0.33). AUC-ROCs of the APPM score in the derivation and validation cohorts were 0.91 and 0.94, respectively. We built and validated a reliable score to predict 28-day mortality in paraquat-poisoned patients at presentation, independently from the ingestion time and serum paraquat measurement.

Citation

Chun-Kuei Chen, Yen-Chia Chen, Bruno Mégarbane, Ying-Tse Yeh, Chung-Hsien Chaou, Chia-Hsun Chang, Chih-Chuan Lin. The acute paraquat poisoning mortality (APPM) score to predict the risk of death in paraquat-poisoned patients. Clinical toxicology (Philadelphia, Pa.). 2022 Apr;60(4):446-450