Embryonic Ectoderm Development (EED) as a Novel Target for Cancer Treatment.

Nicholas Cook, Jianping Chen, Jia Zhou, Daqing Wu

Current topics in medicinal chemistry 2021

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The polycomb repressive complex 2 (PRC2) can methylate at lysine 27 of histone H3 at the trimethylation level (H3K27me3). This leads to gene silencing and is known to be dysregulated in many cancers. PRC2 is made up of three core subunits: EZH2, SUZ12, and EED. EED is essential for the regulation of PRC2 function by binding to H3K27me3. Targeting the allosteric site within EED offers new strategies to disrupt the PRC2 activity. In this minireview, we summarize some of the recent developments in small molecules that target EED and its interaction with other core proteins in the PRC2 complex. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Citation

Nicholas Cook, Jianping Chen, Jia Zhou, Daqing Wu. Embryonic Ectoderm Development (EED) as a Novel Target for Cancer Treatment. Current topics in medicinal chemistry. 2021;21(31):2771-2777