Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks.

Dan Li, Cong Liu

Trends in cell biology 2022 Jan

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Membraneless organelles (MLOs) present as a condensed metastable phase of different proteins and RNAs organized via liquid-liquid phase separation. Recent evidence suggests the extensive incorporation of molecular chaperones into the dynamic assembly of MLOs, where different chaperones coordinate to spatiotemporally maintain the protein homeostasis and avoid abnormal protein aggregation. Copyright © 2021 Elsevier Ltd. All rights reserved.