Lipid specificity of the immune effector perforin.

Adrian W Hodel, Jesse A Rudd-Schmidt, Joseph A Trapani, Ilia Voskoboinik, Bart W Hoogenboom

Faraday discussions 2021 Dec 24

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Perforin is a pore forming protein used by cytotoxic T lymphocytes to remove cancerous or virus-infected cells during the immune response. During the response, the lymphocyte membrane becomes refractory to perforin function by accumulating densely ordered lipid rafts and externalizing negatively charged lipid species. The dense membrane packing lowers the capacity of perforin to bind, and the negatively charged lipids scavenge any residual protein before pore formation. Using atomic force microscopy on model membrane systems, we here provide insight into the molecular basis of perforin lipid specificity.

Citation

Adrian W Hodel, Jesse A Rudd-Schmidt, Joseph A Trapani, Ilia Voskoboinik, Bart W Hoogenboom. Lipid specificity of the immune effector perforin. Faraday discussions. 2021 Dec 24;232(0):236-255