Access to acridones by tandem copper(I)-catalyzed electrophilic amination/Ag(I)-mediated oxidative annulation of anthranils with arylboronic acids.

An efficient and practical approach for the synthesis of medicinally important acridones was developed from anthranils and commercially available arylboronic acids by a tandem copper(I)-catalyzed electrophilic amination/Ag(I)-mediated oxidative annulation strategy. This new and straightforward protocol displayed a broad substrate scope (25 examples) and high functional group tolerance. What's more, a possible mechanistic proposal was also presented.

Citation

Chun-Yong Jiang, Hui Xie, Zhuo-Jun Huang, Jing-Yi Liang, Yan-Xia Huang, Qiu-Ping Liang, Jun-Yi Zeng, Binhua Zhou, Shang-Shi Zhang, Bing Shu. Access to acridones by tandem copper(I)-catalyzed electrophilic amination/Ag(I)-mediated oxidative annulation of anthranils with arylboronic acids. Organic & biomolecular chemistry. 2021 Oct 14;19(39):8487-8491

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PMID: 34545904

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