NMR characterization of streptogramin B and L-156,587, a non-synergistic pair of the streptogramin family antibiotic complexes produced inductively by a combined culture of Streptomyces albogriseolus and Tsukamurella pulmonis.

Naoya Oku, Shion Takemura, Hiroyasu Onaka, Yasuhiro Igarashi

Magnetic resonance in chemistry : MRC 2022 Feb

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The complete 1 H and 13 C NMR characterization of streptogramin B (1), the major component of a clinically important synergistic antibiotic complex, was presented for the first time, along with those of L-156,587 (2), a dehydrated congener of streptogramin A (3). Compounds 1 and 2 were not synergistic and produced by Streptomyces albogriseolus in co-culture with Tsukamurella pulmonis, which poses a question on the adaptive significance of the induced production of this antibiotic pair. © 2021 John Wiley & Sons, Ltd.

Citation

Naoya Oku, Shion Takemura, Hiroyasu Onaka, Yasuhiro Igarashi. NMR characterization of streptogramin B and L-156,587, a non-synergistic pair of the streptogramin family antibiotic complexes produced inductively by a combined culture of Streptomyces albogriseolus and Tsukamurella pulmonis. Magnetic resonance in chemistry : MRC. 2022 Feb;60(2):261-270