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Isopulegol, a pool of abundant chiral terpene, has long served as the starting material for the total synthesis of isopulegol-based drugs. As an inexpensive and versatile starting material, this compound continues to serve modern synthetic chemistry. This review highlights the total syntheses of terpenoids in the period from 1980 to 2020 in which with isopulegol applied as a building block. © 2021 The Chemical Society of Japan & Wiley-VCH GmbH.

Citation

Tam Minh Le, Zsolt Szakonyi. Enantiomeric Isopulegol as the Chiral Pool in the Total Synthesis of Bioactive Agents. Chemical record (New York, N.Y.). 2022 Jan;22(1):e202100194

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PMID: 34553822

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