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Eu3+-Doped nanoceria (Eu:CeO2) with self-integrated catalytic and luminescence sensing functions was synthesized by a simple and gentle one-pot method to build a dual-readout nanozyme platform for organophosphate compound (OPC) sensing in this work. The catalytic degradation of the model substrate of OPC, p-nitrophenyl phosphate (p-NPP), by as-prepared Eu:CeO2 can be completed in 2 min with little influence of temperature and pH values, highlighting the advantages of Eu:CeO2 as an artificial enzyme for dephosphorylation. Most importantly, the characteristic red emission of Eu3+ (592 nm) from Eu:CeO2 can be quenched by p-NPP, accompanied by a color change from colorless to yellow. Based on this, linear ranges of 4-50 μM with a detection limit of 3.3 μM and 1-20 μM with a detection limit of 0.6 μM for p-NPP were obtained by colorimetric and fluorescence methods, respectively. Furthermore, the fluorescence strategy was effectively applied to the determination of ethyl para-nitrophenyl (EPN), one of the most commonly used pesticides, with a detection limit of 5.86 μM. The proposed strategy was also successfully applied to the assay of p-NPP and EPN in real water samples, showing great application prospects in detecting OPC in the environment.


Wendi Lv, Xiaoying Yuan, Chenglu Yan, Qiuting Ma, Bing Wang, Juan Du, Baozhan Zheng, Dan Xiao. Dual-readout performance of Eu3+-doped nanoceria as a phosphatase mimic for degradation and detection of organophosphate. Analytical methods : advancing methods and applications. 2021 Oct 21;13(40):4747-4755

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PMID: 34559169

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