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Both horseradish peroxidase (HRP) and ferrous ion (Fe2+) can degrade organic micropollutants (e.g., sulfamethazine) in the presence of hydrogen peroxide (H2O2), but they have their own disadvantages, such as low degradation efficiency and low pH condition, respectively. In order to overcome the above shortcomings, this study is to develop a HRP-Fenton-like system for sulfamethazine (SMR) efficient degradation by analyzing the optimal reaction conditions, degradation mechanisms, and effect of ions. Results show that HRP and Fe2+ achieve effective coupling by adding trace Fe2+ (≤ 10 μmol/mL) to the HRP system at pH = 5, and the degradation rate of SMR increased by 20.7-42% depending on Fe2+ concentration compared with single HRP treatment. Consumption of H2O2 and quenching of hydroxyl radicals confirmed that HRP dominated SMR removal in the HRP-Fenton-like system. HPLC-MS analysis shows that SMR was degraded by C-S bond breaking, N-S bond breaking, hydroxyl substitution, and rearrangement. Furthermore, Cl-, HCO3-, and NO3- exhibit an acceptable negative effect, while SO42- shows a positive effect on the degradation of SMR. © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.


Hong Liu, Zaihui Huang, Chunguang Liu. Development of a horseradish peroxidase-Fenton-like system for the degradation of sulfamethazine under weak acid condition. Environmental science and pollution research international. 2022 Feb;29(8):12065-12074

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PMID: 34561802

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