Reductive desymmetrization of steroid dimers.

NaBH3CN reduction of symmetric dimers in which two steroid units are linked by a 1,4-dimethylidenebenzene moiety followed two different courses: (a) hydrogenation of the benzylic double bond and (b) reductive F ring opening of the side chain. While courses a and b led to symmetrical dimers, the combination of both pathways produced an unsymmetrical dimer that bears different side chains in each half. The exhaustive NMR characterization of all obtained compounds is presented. Copyright © 2021 Elsevier Inc. All rights reserved.

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Manuel A Ramos-Enríquez, Margarita Romero-Ávila, Martín A Iglesias-Arteaga. Reductive desymmetrization of steroid dimers. Steroids. 2021 Dec;176:108918

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PMID: 34562490

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